Prognostic Implications of Chromosome 17 Abnormalities in the Context of Monosomal Karyotype in Patients With Acute Myeloid Leukemia and Complex Cytogenetics

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• 作者：Aziz Nazha¹ ; Hagop M. Kantarjian¹ ; Vijaya R. Bhatt¹ ; Graciela Nogueras-Gonzalez² ; Jorge E. Cortes¹ ; Tapan Kadia¹ ; Guillermo Garcia-Manero¹ ; Lynne Abruzzo¹ ; Naval Daver¹ ; Naveen Pemmaraju¹ ; Alfonso Quintas-Cardama¹ ; Farhad Ravandi¹ ; Michael Keating¹ ; Gautam Borthakur¹ ; ^{gborthk@mdanderson.org" class="auth_mail}
• 关键词：AML ; Chromosome 17 abnormalities ; Complex karyotype ; Monosomal karyotype
• 刊名：Clinical Lymphoma Myeloma and Leukemia
• 出版年：April, 2014
• 年：2014
• 卷：14
• 期：2
• 页码：163-171
• 全文大小：567 K

文摘

Background

Chromosome 17 abnormalities are associated with poor outcome in leukemias including AML. Recently, MK was introduced as an independent predictor of dismal outcome in AML. The additional prognostic effect of C17 abns in patients with MK in a CK background is not clear.

Patients and Methods

We conducted a retrospective analysis of 1086 patients with newly diagnosed AML treated between January 1998 and December 2007. Patients received treatment with one of the institution's first-line protocols.

Results

Four hundred eighty-three patients had聽CK. Among them, 370 patients (77%) had CK-MK, and 195 patients (53%) had CK-MK-C17 abns. Patients with CK-MK had significantly shorter OS rates compared with patients with CK without MK (4.4 vs. 8 months, respectively; P聽= .002). The median OS for patients with CK-C17 abns was shorter than for patients without C17 abns (4 vs. 6.1 months, respectively; P聽= .004). In a multivariate analysis, the presence of MK among patients with CK was identified as an independent prognostic marker for OS. In addition, presence of C17 abns had a significant negative effect on OS聽among patients with CK-MK (P聽= .04).

Conclusion

Among patients with CK-AML, MK was associated with poor聽outcomes. Additional presence of C17 abns further worsens the outcome in these particularly poor-risk patients with聽AML.