Vitamin D3 Supplementation During Pregnancy and Lactation Improves Vitamin D Status of the Mother-Infant Dyad

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• 作者：Doria K. Thiele ; ^{thiele@ohsu.edu}Author Vitae ; Jody RalphAuthor Vitae ; Maher El-MasriAuthor Vitae ; Cindy M. AndersonAuthor Vitae
• 关键词：breastfeeding ; vitamin D deficiency ; vitamin D3 supplementation
• 刊名：Journal of Obstetric, Gynecologic & Neonatal Nursing
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：46
• 期：1
• 页码：135-147
• 全文大小：693 K
• 卷排序：46

文摘

To identify the combined effect of prenatal and postnatal vitamin D3 supplementation on the vitamin D status of pregnant and lactating women and their exclusively breastfed infants.DesignDouble-blind, randomized controlled trial.SettingUpper Midwestern U.S., hospital-based obstetric practice.ParticipantsPregnant women (N = 13) planning to exclusively breastfeed were randomized at 24 to 28 weeks gestation to receive vitamin D3 at a dosage of 400 IU (control group, n = 6) or 3,800 IU (intervention group, n = 7) daily through 4 to 6 weeks postpartum. Vitamin D status was determined at enrollment and in mother–infant dyads at 24 to 72 hours after birth and 4 to 6 weeks postpartum.MethodsSerum 25-hydroxyvitamin D levels were measured to determine the effect of vitamin D3 supplementation on the vitamin D status of mothers and infants. Analysis of covariance was used to compare differences in 25-hydroxyvitamin D levels between the control and intervention groups.ResultsThe mothers’ vitamin D levels were significantly higher in the intervention group than in the control group at birth (p = .044) and at 4 to 6 weeks postpartum (p = .002). Infants in the intervention group had significantly higher vitamin D levels at birth (p = .021) and nonsignificant, clinically relevant increases at 4 to 6 weeks of age (p = .256). No differences were found between maternal groups in serum calcium or parathyroid hormone levels.ConclusionPrenatal to postpartum vitamin D3 supplementation is an effective intervention to increase a mother’s vitamin D status and to promote optimal vitamin D status in newborns and exclusively breastfed infants.