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Recurring sequence-structure motifs in (βα)8-barrel proteins and experimental optimization of a chimeric protein designed based on such motifs
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文摘
The βα and αβ modules of TIM barrel proteins were clustered based on structure and sequence. A number of recurring motifs have been identified. A chimeric protein A0 was created by using the recurring motifs as interfaces. A0 was significantly improved by six rounds of directed evolution.

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