Acute paraquat exposure impairs colonic motility by selectively attenuating nitrergic signalling in the mouse
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- 作者：Lucy Diss ; Sarah Dyball ; Tina Ghela ; Jonathan Golding ; Rachel Morris ; Stephen Robinson ; Rosemary Tucker ; Talia Walter ; Paul Young ; Marcus Allen ; Sara Fidalgo ; Paul Gard ; Jon Mabley ; Bhavik Patel ; Prabal Chatterjee ; Mark Yeoman ; m.s.yeoman@brighton.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Colon motility ; Colonic migrating motor complex ; Paraquat and nitric oxide
- 刊名：Autonomic Neuroscience: Basic and Clinical
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：195
- 期：Complete
- 页码：8-15
- 全文大小：1080 K
文摘
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Acute exposure to paraquat significantly impairs colonic transit in the mouse.
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Paraquat reduces the amplitude of CMMCs and selectively inhibits NO signalling.
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These effects are not due to changes in oxidative stress, inflammation or Complex 1 activity.