Interplay of the modified nucleotide phosphoadenosine 5′-phosphosulfate (PAPS) with global regulatory proteins in Escherichia coli: modulation of cyclic AMP (cAMP)-dependent gene expression and interaction with the HupA regulatory protein
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- 作者：Francesca Longoa ; francesca.longo@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Sara Mottab ; sara.motta@itb.cnr.it" class="auth_mail" title="E-mail the corresponding author ; Pierluigi Maurib ; pierluigi.mauri@itb.cnr.it" class="auth_mail" title="E-mail the corresponding author ; Paolo Landinia ; paolo.landini@unimi.it" class="auth_mail" title="E-mail the corresponding author ; Elio Rossia ; 1 ; elioros@biosustain.dtu.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Phosphoadenosine 5&prime ; -phosphosulphate (PAPS) ; Cyclic adenosine monophosphate (cAMP) ; Adenylate cyclase CyaA ; Histone-like HU protein ; Gene expression regulation ; Signal molecule
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 November 2016
- 年：2016
- 卷：259
- 期：part_PA
- 页码：39-47
- 全文大小：1177 K
文摘
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Phosphoadenosine 5′-phosphosulfate (PAPS) acts as a global signal molecule in Escherichia coli.
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PAPS accumulation stimulates cAMP-CRP-dependent gene expression.
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PAPS/cAMP interplay affects composition of bacterial cell surface-associated structures.
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PAPS (or PAPS reductase) interacts with the global regulator and nucleoid-associated protein HupA.