- 作者：Marilou Rebi¨¨re ; Frederik A. Verburg ; Moritz Palmowski ; Thomas Krohn ; Hubertus Pietsch ; Christiane K. Kuhl ; Felix M. Mottaghy ; Florian F. Behrendt
- 关键词：PET/CT ; Attenuation correction ; Contrast medium ; Multiphase MDCT ; Iodine concentration
- 刊名：European Journal of Radiology
- 出版年：2012
- 出版时间：August, 2012
- 年：2012
- 卷：81
- 期：8
- 页码：e862-e869
- 全文大小：434 K
Purpose
To evaluate the influence of multiphase CT scanning and different intravenous contrast media on contrast enhancement, attenuation correction and image quality in combined PET/CT.Material and methods
140 patients were prospectively enrolled for F-18-FDG-PET/CT including a low-dose unenhanced, arterial and venous contrast enhanced CT. The first (second) 70 patients, received contrast medium with 370 (300) mg iodine/ml. The iodine delivery rate (1.3 mg/s) and total iodine load (44.4 g) were identical for both groups. Contrast enhancement and maximum and mean standardized FDG uptake values (SUVmax and SUVmean) were determined for the un-enhanced, arterial and venous PET/CT at multiple anatomic sites and PET reconstructions were visually evaluated.
Results
Arterial contrast enhancement was significantly higher for the 300 mg/ml contrast medium compared to 370 mg I/ml at all anatomic sites. Venous enhancement was not different between the two contrast media. SUVmean and SUVmax were significantly higher for the contrast enhanced compared to the non-enhanced PET/CT at all anatomic sites (all P < 0.001). Tracer uptake was significantly higher in the arterial than in the venous PET/CT in the arteries using both contrast media (all P < 0.001). No differences in tracer uptake were found between the contrast media (all P > 0.05). Visual assessment revealed no relevant differences between the different PET reconstructions.
Conclusions
There is no relevant qualitative influence on the PET scan from the use of different intravenous contrast media in its various phases in combined multiphase PET/CT. For quantitative analysis of tracer uptake it is required to use an identical PET/CT protocol.