Urinary bladder hypersensitivity and dysfunction in female mice following early life and adult stress
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- 作者：Angela N. Pierce ; Elizabeth R. Di Silvestro ; Olivia C. Eller ; Ruipeng Wang ; Janelle M. Ryals ; Julie A. Christianson
- 关键词：NMS ; neonatal maternal separation ; WAS ; water avoidance stress ; PAR2 ; protease activated receptor 2 ; TRPA1 ; transient receptor potential ankyrin 1 ; IC/PBS ; interstitial cystitis/painful bladder syndrome ; CRF ; corticotropin-releasing factor ; HPA ; hypothalamic-pituitary-adrenal ; GR ; glucocorticoid receptor ; MR ; mineralocorticoid receptor ; NGF ; nerve growth factor ; SP ; substance P ; TRPV1 ; transient receptor potential vanilloid 1 ; VMR ; visceromotor response ; UBD ; urinary bladder distension ; CRD ; col
- 刊名：Brain Research
- 出版年：2016
- 出版时间：15 May 2016
- 年：2016
- 卷：1639
- 期：Complete
- 页码：58-73
- 全文大小：2723 K
文摘
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Neonatal maternal separation increases bladder sensitivity in adult female mice.
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Water avoidance stress exacerbates early life stress-induced bladder sensitivity.
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Hippocampal regulation of the HPA axis is disrupted by early life and adult stress.
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Early life and adult stress increase mast cell degranulation in the bladder.
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The colorectum is largely unaffected by early life and adult stress in mice.
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