RNA-seq analysis of hippocampal tissues reveals novel candidate genes for drug refractory epilepsy in patients with MTLE-HS
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- 作者：Aparna Banerjee Dixita ; aparnabanerjeedixit@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jyotirmoy Banerjeea ; Arpna Srivastavab ; Manjari Tripathic ; Chitra Sarkard ; Aanchal Kakkard ; Mukesh Jaine ; P. Sarat Chandrab ; saratpchandra3@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：MTLE-HS ; mesial temporal lobe epilepsy-hippocampal sclerosis ; RNAseq ; RNA sequencing ; AEDs ; anti-epileptic drugs ; DRE ; drug resistant epilepsy ; MDTs ; multi drug transporters ; NGS ; next generation sequencing ; ATL ; anterior temporal lobectomy ; AH ; amygdalo-hippocampectomy ; EEG ; electroencephalogram ; GO ; Gene Ontology
- 刊名：Genomics
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：107
- 期：5
- 页码：178-188
- 全文大小：1208 K
文摘
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RNAseq analysis of hippocampal tissue from MTLE patients revealed potential molecules that may play crucial role in the pathogenesis of MTLE.
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FN1 is central in our network analysis and demands further validation in serum and CSF samples for its potential as biomarker.
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Three major hubs identified include molecules involved in modulation of neuronal networks, synaptic transmission, and neuroinflammation.
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These hubs support the intrinsic severity hypothesis of pharmacoresistance.