Proteomic analysis of mucopolysaccharidosis I mouse brain with two-dimensional polyacrylamide gel electrophoresis

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• 作者：Li Ou^a ; ^{oulileo@umn.edu} ; Michael J Przybilla^b ; Chester B Whitley^a ; ^b
• 关键词：Mucopolysaccharidosis ; Proteomics ; 2D-PAGE
• 刊名：Molecular Genetics and Metabolism
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：120
• 期：1-2
• 页码：101-110
• 全文大小：1363 K
• 卷排序：120

文摘

We conducted 2D PAGE analysis of MPS I mice brain. The proteins identified in this study would provide potential biomarkers for diagnostic and therapeutic studies of MPS I. Metabolism pathways, intracellular ionic homeostasis and the cytoskeleton are implicated in the neuropathology of MPS I disease.