In-silico analysis of putative HCV epitopes against Pakistani human leukocyte antigen background: An approach towards development of future vaccines for Pakistani population
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- 作者：Naeem Mahmood Ashrafa ; naeem.mahmood@uog.edu.pk" class="auth_mail" title="E-mail the corresponding author ; Muhammad Bilalb ; Malik Siddique Mahmoodc ; Aadil Hussaina ; Muhammad Zubair Mehbooba
- 关键词：Epitope-based vaccines ; HCV genotypes ; HLA ; Pakistani population
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：43
- 期：Complete
- 页码：58-66
- 全文大小：1009 K
文摘
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Conserved epitopes of HCV from NS4B, NS5A and NS3 have been predicted.
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Three HLA - I & one HLA -II restricted epitopes have been selected for final vaccine cocktail and population coverage.
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75.53% and 70.77% population coverage for Pakistani Asian and Mixed respectively have been estimated.