Long-term effects of methamphetamine exposure in adolescent mice on the future ovarian reserve in adulthood
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- 作者：Lan Wanga ; Guoqiang Qub ; Xiyuan Donga ; Kai Huanga ; c ; Molly Kumard ; Licheng Jia ; Ya Wanga ; Junning Yaoa ; Shulin Yanga ; Ruxing Wua ; Hanwang Zhanga ; hwzhang@tjh.tjmu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：MA ; methamphetamine ; AMH ; anti-Mullerian hormone ; LH ; luteinizing hormone ; FSH ; follicle stimulating hormone
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：3 February 2016
- 年：2016
- 卷：242
- 期：Complete
- 页码：1-8
- 全文大小：2246 K
文摘
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The long-term abuse of methamphetamine in the adolescent period causes mitochondrial damage in murine female ovarian tissue.
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The long-term abuse of methamphetamine in the adolescent period activates the Bcl-2 and Bax apoptosis signaling pathways and leads to a decrease of anti-Mullerian hormone expression in the ovary.
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Adolescent MA abuse results in a reduction of the ovarian follicle pool.