Lenvatinib: Role in thyroid cancer and other solid tumors
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- 作者：Maria E. Cabanillas ; mcabani@mdanderson.org" class="auth_mail" title="E-mail the corresponding author ; Mouhammed Amir Habra MAHabra@mdanderson.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Refractory ; Differentiated ; Multikinase ; Medullary ; Survival ; Advanced
- 刊名：Cancer Treatment Reviews
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：42
- 期：Complete
- 页码：47-55
- 全文大小：566 K
文摘
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We review advanced thyroid cancer (TC) etiology and signaling pathway mutations.
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We review the mechanism of action and role of tyrosine kinase inhibitors (TKIs).
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Lenvatinib, a multitargeted TKI, has broad antitumor and antiangiogenic activity.
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We review phase III radioactive iodine-refractory differentiated TC results.
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Lenvatinib shows superior progression-free survival and overall response rate.