Hematopoietic stem and multipotent progenitor cells produce IL-17, IL-21 and other cytokines in response to TLR signals associated with late apoptotic products and augment memory Th17 and Tc17 cells in the bone marrow of normal and lupus mice
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- 作者：Ching-I Chena ; Li Zhanga ; Syamal K. Dattaa ; b ; skd257@northwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：HSPC ; hematopoietic stem and progenitor cells ; LSK ; Lineage&minus ; ; Sca-1+ ; cKit+ cells ; LSKen ; LSK-enriched cells ; LT-HSC ; long-term hematopoietic stem cells ; ST-HSC ; short-term hematopoietic stem cells ; MPP ; multipotent progenitor cells ; MKP ; megakaryocyte progenitor cells ; MEP ; bi-potent megakaryocyte- and megakaryocyte&ndash ; erythroid progenitor cells ; MM ; MKP and MEP cells ; MDP ; macrophage dendritic cell progenitors ; DAMP ; damage associated molecular pattern ; B/WF1 ; (NZB ; ×
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：162
- 期：Complete
- 页码：9-26
- 全文大小：3318 K
文摘
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Normal marrow HSPC produce IL-17/21 & other cytokines on apoptosis related TLR agonist stimulation.
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Apoptotic product/TLR stimulated normal HSPC augment IL-17+ memory CD4 & CD8 T cells in bone marrow.
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Lupus bone marrow HSPC are endogenously pre-stimulated to produce IL-17/IL-21 and other cytokines.
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In contrast to bone marrow HSPC, megakaryocyte progenitor cells (MKP) do not produce IL-17/IL-21.
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Unlike HSPC, MKP can process & present apoptotic antigens, augmenting autoimmune Th17 in lupus.