The effect of multivalent cations and Tau on paclitaxel-stabilized microtubule assembly, disassembly, and structure
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- 作者：Cyrus R. Safinyaa ; b ; c ; safinya@mrl.ucsb.edu" class="auth_mail" title="E-mail the corresponding author ; Peter J. Chunga ; b ; c ; Chaeyeon Songa ; b ; c ; Youli Lid ; Kai K. Ewerta ; b ; c ; Myung Chul Choie
- 关键词：Microtubule ; Multivalent counter-ions ; Microtubule-associated protein Tau ; Intrinsically disordered proteins ; Correlated ion density fluctuations ; Ion specific effects
- 刊名：Advances in Colloid and Interface Science
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：232
- 期：Complete
- 页码：9-16
- 全文大小：1280 K
文摘
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We describe nanoscale assemblies in biological materials systems.
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We focus on effects of multivalent cations on microtubule ordering and disassembly.
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Divalent cations either bundle or depolymerize paclitaxel-stabilized microtubules.
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The ion concentration for depolymerization decreases with increasing atomic number.
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We describe microtubule-inspired lipid cylindrical nanostructures for applications.
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