Antimitotic activity of the pyrimidinone derivative py-09 on sea urchin embryonic development
详细信息 查看全文
- 作者：Dalliane Macedoa ; Francisco Jaime Bezerra Mendonç ; a Jú ; niorb ; Ricardo Olimpio de Mourab ; a nd Luis Fernando Marques-Santosa ; marques@ltf.ufpb.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：a.u. ; arbitrary unit ; FSW ; filtered seawater ; MDR ; multidrug resistance ; MXR ; multixenobiotic resistance ; REV205 ; reversin 205 ; VP ; verapamil ; VB ; vinblastine
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：72-85
- 全文大小：2283 K
文摘
- •
We investigate the effect of Py-09 on sea urchin embryonic development.
- •
Py-09 exhibited antimitotic activity and blocked sea urchin embryonic development.
- •
Py-09 induced morphological changes and the loss of ΔΨm without altering ROS levels.
- •
Py-09 is not an ABC transporter substrate and does not circumvent the MXR phenomenon.