Distinct behavioral phenotypes in novel “fast” kindling-susceptible and “slow” kindling-resistant rat strains selected by stimulation of the hippocampal perforant path
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- 作者：Tomer Langberg1 ; langberg.tomer@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Ryan Dashek2 ; dashek@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Bernard Mulvey3 ; mulveyb@wusm.wustl.edu" class="auth_mail" title="E-mail the corresponding author ; Kimberly A. Miller4 ; kim_a_miller@comcast.net" class="auth_mail" title="E-mail the corresponding author ; Susan Osting smknodel@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Carl E. Stafstrom5 ; cstafst1@jhmi.edu" class="auth_mail" title="E-mail the corresponding author ; Thomas P. Sutula ; sutula@neurology.wisc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：SD ; Sprague&ndash ; Dawley ; PPKS ; Perforant Path Kindling Susceptible ; PPKR ; Perforant Path Kindling Resistant ; AD ; After discharge ; ADT ; After discharge threshold ; CS ; Conditioning stimulus ; US ; Unconditioned stimulus
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：85
- 期：Complete
- 页码：122-129
- 全文大小：565 K
文摘
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Sprague–Dawley rats selected and bred for “fast” or “slow” perforant path kindling.
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After 15 generations “fast” rats were Perforant Path Kindling-Susceptible (PPKS).
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After 15 generations “slow” rats were Perforant Path Kindling-Resistant (PPKR).
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PPKS rats had increased open field activity and impaired hippocampal spatial memory.
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Genetic background of PPKS/PPKR strains influences circuit plasticity and behavior.