Acremomannolipin A, the potential calcium signal modulator with a characteristic glycolipid structure from the filamentous fungus Acremonium strictum
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- 作者：Reiko Sugiura ; Ayako Kita ; Nozomi Tsutsui ; Osamu Muraoka ; Kanako Hagihara ; Nanae Umeda ; Tatsuki Kunoh ; Hirofumi Takada ; Dai Hirose
- 关键词：Glycolipid ; Acremomannolipin A ; Calcium signal modulator ; Acremonium strictum ; Phenotypic screen
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：1 November, 2012
- 年：2012
- 卷：22
- 期：21
- 页码：6735-6739
- 全文大小：614 K
文摘
By the newly developed assay method, the glycolipid Acremomannolipin A (1) was isolated from a filamentous fungus Acremonium strictum as a potential calcium signal modulator. The structure of 1 elucidated on the basis of intensive spectroscopic analyses as well as its degradation studies is quite unique: the d-mannopyranose is connected to d-mannitol through a ¦Â-glycoside linkage; all the hydroxyls in the mannose are highly masked as peresters with aliphatic acids, and this moiety is made hydrophobic, whereas the mannitol part exhibits a highly hydrophilic property. The compound (1) showed the characteristic bioactivity property, enabling calcineurin deletion cells to grow in the presence of Cl?, which would be caused by calcium signal modulating. The activity was so potent as to exert the effect at a concentration of 200 nM.