Multivariate optimization of the hollow fibre liquid phase microextraction of muscimol in human urine samples
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- 作者：Somandla Ncubea ; Anna Poliwodab ; Hlanganani Tutua ; Piotr Wieczorekb ; Luke Chimukaa ; luke.chimuka@wits.ac.za" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aliquat 336 ; N methyl-N ; N ; N-trioctylammonium chloride ; AP ; acceptor phase ; CCD ; central composite design ; DEHPA ; di-(2-ethylhexyl) phosphoric acid ; DHE ; dihexyl ether ; DOE ; design of experiment ; DP ; donor phase ; EF ; enrichment factor ; HF ; hollow fibre ; HF-LPME ; hollow fibre-liquid phase microextraction ; HILIC ; hydrophilic interaction liquid chromatography ; MUS ; muscimol ; MeCN ; acetonitrile ; MeOH ; methanol ; SLM ; supported liquid membrane ; TA ; tryptamine ; TRP ; tryptophan
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：15 October 2016
- 年：2016
- 卷：1033-1034
- 期：Complete
- 页码：372-381
- 全文大小：1228 K
文摘
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Hollow fibre-based LPME for the extraction of hallucinogenic muscimol, tryptophan and tryptamine from urine is reported for the first time.
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Central composite designs and desirability functions were used during optimizations.
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Stirring rate is the most important factor for the effective transfer of very polar compounds during HF-LPME.
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Good values for method validation parameters were obtained.
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The HF-LPME approach is a viable alternative for extraction of muscimol from urine samples.
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