GABAergic control of neostriatal dopamine D₂ receptor binding and behaviors in the rat

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• 作者：Susanne Nikolaus^a ; ^{susanne.nikolaus@uni-duesseldorf.de} ; Markus Beu^a ; Maria Angelica de Souza Silva^b ; Joseph P. Huston^b ; Christina Antke^a ; Hans-Wilhelm Mü ; ller^a ; Hubertus Hautzel^a
• 关键词：D2 receptor ; [123I]IBZM ; GABAA receptor ; Muscimol ; Bicuculline ; Time-behavior curves ; Small animal SPECT
• 刊名：Pharmacology Biochemistry and Behavior
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：153
• 期：Complete
• 页码：76-87
• 全文大小：1727 K
• 卷排序：153

文摘

Muscimol decreased motor/exploratory behavior. Bicucullin increased motor/exploratory behavior. Muscimol but not bicuculline decreased D2 receptor binding in the rat striatum. Results indicate GABAergic control over D2 receptor binding in relation to behavior.