The -94Ins/DelATTG polymorphism in NFκB1 promoter modulates chronic hepatitis C and liver disease progression
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- 作者：Fatima-Zohra Fakhira ; b ; Mustapha Lkhiderc ; Wafaa Badred ; Rhimou Alaouid ; Pascal Pineaue ; Sayeh Ezzikouria ; sayeh.ezzikouri@pasteur.ma" class="auth_mail" title="E-mail the corresponding author ; Soumaya Benjellouna ; soumaya.benjelloun@pasteur.ma" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCV ; Hepatitis C Virus ; PRR ; pattern recognition receptor ; NF-κB ; nuclear factor-kappa B ; TNFR1 ; tumor necrosis factor receptor 1 ; NS5B ; non-structural protein 5B ; IκB ; inhibitor of kappa B ; TNFA ; tumor necrosis factor alpha ; IL8 ; interleukin 8 ; IL1B ; interleukin 1B
- 刊名：Infection, Genetics and Evolution
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：39
- 期：Complete
- 页码：141-146
- 全文大小：416 K
文摘
- istitem" id="list_l0005">
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id="p0005">Hepatitis C Virus may induce liver cancer through chronic inflammation and promotion of cirrhosis.
- el">•
id="p0010">NF-κB pathway is a key regulator of inflammatory process and may contribute to liver tumorigenesis.
- el">•
id="p0015">The NF-κB polymorphism is not associated with natural clearance of HCV infection.
- el">•
id="p0020">The NF-κB polymorphism may modulate the progression of HCV infection to advanced liver disease.