Cellular replication limits in the Luria-Delbrück mutation model
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- 作者：Ignacio A. Rodriguez-Brenesa ; b ; iarodrig@uci.edu" class="auth_mail" title="E-mail the corresponding author ; Dominik Wodarzb ; a ; Natalia L. Komarovaa ; b
- 关键词：Hayflick&rsquo ; s limit ; Stochastic analysis ; Fluctuation analysis ; Cancer ; Evolution
- 刊名：Physica D: Nonlinear Phenomena
- 出版年：2016
- 出版时间：1 August 2016
- 年：2016
- 卷：328-329
- 期：Complete
- 页码：44-51
- 全文大小：528 K
文摘
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First Luria–Delbrück model that takes into account cellular replication limits.
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Model the emergence of mutants that escape replicative senescence.
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Results on the mean, variance, distribution, and asymptotic behavior of the mutant population.
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Discuss applications, including telomere crisis and fluctuation analysis.