Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma Patients
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- 作者：Diogo Ribeiro1 ; diogo.ribeiro@ki.se" class="auth_mail" title="E-mail the corresponding author ; Marcus D.R. Klarqvist1 ; 4 ; 5 ; Ulrica K. Westermark1 ; 6 ; Ganna Oliynyk1 ; Johanna Dzieran1 ; Anna Kock2 ; Carolina Savatier Banares1 ; Falk Hertwig3 ; John Inge Johnsen2 ; Matthias Fischer3 ; 7 ; Per Kogner2 ; Jakob Lové ; n1 ; 8 ; Marie Arsenian Henriksson1 ; marie.arsenian.henriksson@ki.se" class="auth_mail" title="E-mail the corresponding author
- 关键词：neuroblastoma ; MYCN ; miR-17&sim ; 92 ; miRNAs ; nuclear hormone receptors ; glucocorticoid receptor ; MYC inhibitor ; differentiation ; cancer therapy
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 July 2016
- 年：2016
- 卷：16
- 期：4
- 页码：979-993
- 全文大小：6044 K
文摘
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The MYCN-regulated miR-17∼92 cluster targets nuclear hormone receptors
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An NHR signature is associated with neural differentiation and patient survival
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The induction of MYCN or miR-17∼92 attenuates glucocorticoid receptor signaling
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Combined MYCN inhibition and GR activation drive differentiation and ease tumor burden