Antibody and cellular immune responses of naïve mares to repeated vaccination with an inactivated equine herpesvirus vaccine
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- 作者：B. Wagnera ; bw73@cornell.edu" class="auth_mail" title="E-mail the corresponding author ; L.B. Goodmana ; S. Babasyana ; H. Freera ; S. Torsteinsdó ; ttirb ; V. Svanssonb ; S. Bjö ; rnsdó ; ttirc ; G.A. Perkinsd
- 关键词：AAEP ; American Association of Equine Practitioners ; CHO cells ; Chinese hamster ovary cells ; CTL ; cytotoxic T-lymphocyte ; ELISA ; enzyme-linked immunosorbent assay ; EHM ; equine herpes myeloencephalopathy ; EHV-1 ; equine herpesvirus type 1 ; gC ; glycoprotein C ; gD ; glycoprotein D ; IFN-γ ; interferon-gamma ; Ig ; immunoglobulin ; IgG ; immunoglobulin G ; IL-4 ; interleukin 4 ; MFI ; median fluorescence intensity ; PBMC ; peripheral blood mononuclear cells ; PBS ; phosphate buffered saline ; SN ; serum neutralization
- 刊名：Vaccine
- 出版年：2015
- 出版时间：13 October 2015
- 年：2015
- 卷：33
- 期：42
- 页码：5588-5597
- 全文大小：1344 K
文摘
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Repeated EHV vaccination <90 days apart can result in decreasing antibody levels.
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A novel EHV-1 Multiplex assay improves EHV-specific antibody quantification.
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EHV vaccination using an inactivated vaccine induced predominately IgG1 and IgG4/7 antibodies.
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EHV vaccination also induced IFN-γ production via Th1-cells but not by CD8+ cells.
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Repeated EHV vaccination protocols and immune parameters should be re-evaluated to optimize protection.