Expedious synthesis for α, β-unsaturated coumarin derivatives using boran chelates: A novel class of potential antibacterial and antioxidant agents

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• 作者：Naceur Hamdi ; Feten Bouabdallah ; Antonio Romerosa ; Rached Benhassen
• 关键词：Coumarin derivatives ; Boron compounds ; Chalcone ; Electronic absorption spectra
• 刊名：Comptes Rendus Chimie
• 出版年：2010
• 出版时间：October 2010
• 年：2010
• 卷：13
• 期：10
• 页码：1261-1268
• 全文大小：317 K

文摘

A new family of coumarin derivatives (4a–i) containing a chalcone moiety was synthesized by condensation of 3-acetyl-4-difluoro boryloxycoumarin (2) with aryl and heteroaryl aldehydes with piperidine in chloroform. Resulting compounds were characterized by IR, ¹³C, ¹H NMR and UV visible spectroscopy. Compound 3-((2E)-3-(3,4,5-Trimethoxy-phenyl)prop-2-enoyl)-2(H)-chromen-2-one (4g) was characterized by single crystal X-ray diffraction. The antioxidant and antibacterial activities of the obtained compounds 4a-i was evaluated. The biological activity found for these compounds is discussed against their structural features, physical and chemical properties.