The effect of dopamine on adult hippocampal neurogenesis

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• 作者：Naoki Takamura ; Shin Nakagawa ; Takahiro Masuda ; Shuken Boku ; Akiko Kato ; Ning Song ; Yan An ; Yuji Kitaichi ; Takeshi Inoue ; Tsukasa Koyama ; Ichiro Kusumi
• 关键词：ADP ; adult dentate gyrus-derived neural precursor cells ; bFGF ; basic fibroblast growth factor ; BrdU ; 5-bromo-2-deoxyuridine ; CNTF ; ciliary neurotrophic factor ; FBS ; fetal bovine serum ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; GCL ; granule cell layer ; GFAP ; glial fibrillary acidic protein ; HBSS ; hanks balanced salt solution ; NPC ; neural precursor cells ; PBS ; phosphate buffered saline ; PS ; penicillin&ndash ; streptomycin ; SGZ ; subgranular zone ; SVZ ; subventricular zone ; SSRI ; selective serot
• 刊名：Progress in Neuro-Psychopharmacology and Biological Psychiatry
• 出版年：3 April, 2014
• 年：2014
• 卷：50
• 期：Complete
• 页码：116-124
• 全文大小：1269 K

文摘

Cumulative studies indicated that adult hippocampal neurogenesis might be involved in the action mechanism of antidepressant drugs and/or the pathophysiology of depression. Dopamine (DA) is involved in the regulation of motivation, volition, interest/pleasure, and attention/concentration, all of which are likely to be impaired in depressed patients. Several previous reports suggest that depression may often be accompanied by a relative hypo-dopaminergic state, and some DA receptor agonists are beneficial effects in the treatment for refractory and bipolar depression. In the present study, to clarify the direct effect of DA on neural progenitor cells, we examined the effect of DA on the proliferation of adult rat dentate gyrus-derived neural precursor cells (ADPs). In addition, we examined the effect of DA receptor agonists on adult rat hippocampal neurogenesis in vivo. Results showed that DA promoted the increase of ADPs via D1-like receptor and D1-like receptor agonist promoted the survival of newborn cells in the adult hippocampus. On the contrary, D2-like receptor agonist did not affect both proliferation and survival. These results suggested that DA might play, at least in part, a role in adult hippocampal neurogenesis via D1-like receptor and the activation of D1-like receptor has a therapeutic potential for depression.