Tescalcin is a potential target of class I histone deacetylase inhibitors in neurons

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• 作者：Gakuya Takamatsu^a ; ^b ; Chiaki Katagiri^a ; ^c ; Tsumuraya Tomoyuki^a ; Chigusa Shimizu-Okabe^d ; Wakako Nakamura^a ; Mariko Nakamura-Higa^a ; Tomoko Hayakawa^a ; Shigeo Wakabayashi^e ; Tsuyoshi Kondo^b ; Chitoshi Takayama^d ; Masayuki Matsushita^a ; ^{masayuki@med.u-ryukyu.ac.jp}
• 关键词：Tescalcin ; Calcineurin B homologous protein ; Histone deacetylase ; Valproate acid ; Trichostatin A ; Suberoylanilide hydroxamic acid
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1327-1333
• 全文大小：1330 K
• 卷排序：482

文摘

We found tescalcin (Tesc) as a potential target gene of class I HDAC inhibitors in neuron. Class I HDAC inhibitors strongly induced TESC expression in hippocampal neurons. TESC overexpression promoted neurite outgrowth and branching in neurons. A Ca2+-unbound EF-hand mutant of tescalcin slightly reduced neurite outgrowth. A potentially key role for TESC in class I HDAC inhibitor treatment is predicted.