COMT Val¹⁵⁸Met polymorphism is associated with post-traumatic stress disorder and functional outcome following mild traumatic brain injury

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• 作者：Ethan A. Winkler^a ; ^b ; ¹ ; John K. Yue^a ; ^b ; ¹ ; Adam R. Ferguson^a ; ^b ; Nancy R. Temkin^c ; Murray B. Stein^d ; ^e ; Jason Barber^c ; Esther L. Yuh^b ; ^f ; Sourabh Sharma^a ; ^b ; Gabriela G. Satris^a ; ^b ; Thomas W. McAllister^g ; Jonathan Rosand^h ; ⁱ ; Marco D. Sorani^a ; ^b ; Hester F. Lingsma^j ; Phiroz E. Tarapore^a ; ^b ; Esteban G. Burchard^k ; Donglei Hu^k ; Celeste Eng^k ; Kevin K.W. Wang^l ; Pratik Mukherjee^b ; ^f ; David O. Okonkwo^m ; Ramon Diaz-Arrastiaⁿ ; Geoffrey T. Manley^a ; ^b ; ^{manleyg@neurosurg.ucsf.edu} ; ; the TRACK-TBI Investigators²
• 关键词：Traumatic brain injury ; Genetic factors ; PTSD ; Outcome measures ; Human studies
• 刊名：Journal of Clinical Neuroscience
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：35
• 期：Complete
• 页码：109-116
• 全文大小：466 K
• 卷排序：35

文摘

Genetic polymorphisms may contribute to clinical variability after mild TBI. The COMT Met158 allele is associated with lower rates of PTSD following mild TBI. The COMT Met158 allele is associated with better outcome following mild TBI.