Preparation of chitosan-based multifunctional nanocarriers overcoming multiple barriers for oral delivery of insulin
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- 作者：Lei Lia ; Guohua Jianga ; b ; c ; ghjiang_cn@zstu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Weijiang Yua ; Depeng Liua ; Hua Chena ; Yongkun Liua ; Zaizai Tonga ; Xiangdong Kongd ; Juming Yaoa ; b ; c
- 关键词：Nanocarriers ; Chitosan ; Insulin ; Oral delivery ; Hypoglycemic effect
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P1
- 页码：278-286
- 全文大小：1616 K
文摘
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Chitosan-based multifunctional nanocarriers for oral delivery of insulin were prepared.
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The resultant nanocarriers exhibited low cytotoxicity against HT-29 cells.
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The loaded insulin exhibited excellent stability against pepsin and pancreatin.
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The hypoglycemic effect for oral delivery of insulin was studied in vivo.
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The findings provide a new way in diabetes treatment via oral ingestion.