Completely disintegrable redox-responsive poly(amino acid) nanogels for intracellular drug delivery

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• 作者：Chan Woo Park^a ; ^b ; Hee-Man Yang^b ; Min-Ah Woo^a ; ^c ; Kwang Se Lee^a ; Jong-Duk Kim^a ; ^{kjd@kaist.ac.kr}
• 关键词：Nanogel ; Disulfide ; Drug delivery ; Reduction-responsive
• 刊名：Journal of Industrial and Engineering Chemistry
• 出版年：2017
• 出版时间：25 January 2017
• 年：2017
• 卷：45
• 期：Complete
• 页码：182-188
• 全文大小：1997 K
• 卷排序：45

文摘

We report a disulfide cross-linked poly(amino acid) nanogel that is completely disintegrable in the intracellular reductive environment by cleavage of the disulfide cross-links. A short-poly(ethylene glycol)-grafted poly(succinimide) was synthesized as an amphiphilic prepolymer to prepare poly(amino acid) nanogels that consisted of a hairy PEG shell and a disulfide cross-linked poly(amino acid) core. The nanogels were prepared by chemical conversion of the hydrophobic core of the cross-linked micelles into a hydrophilic poly(aspartic acid) network. The nanogels disintegrated into fully water-soluble and biocompatible residues in the reductive condition. Post-endocytic disintegration of the nanogel improved nuclear translocation and efficacy of an anticancer drug.