Chitosan-g-poly(N-isopropylacrylamide) based nanogels for tumor extracellular targeting

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• 作者：Cunxian Duan^a ; Dianrui Zhang^a ; ^{zhangdianrui2006@163.com} ; Feihu Wang^a ; Dandan Zheng^a ; Lejiao Jia^a ; Feifei Feng^a ; Yue Liu^a ; Yancai Wang^a ; Keli Tian^b ; Fengshan Wang^c ; Qiang Zhang^d
• 关键词：Nanogels ; Chitosan ; N-isopropylacrylamide ; Tumor extracellular pH ; Oridonin
• 刊名：International Journal of Pharmaceutics
• 出版年：2011
• 出版时间：16 May 2011
• 年：2011
• 卷：409
• 期：1-2
• 页码：252-259
• 全文大小：1416 K

文摘

The principle objective of this research was to develop and characterize pH-responsive and biocompatible nanogels as a tumor-targeting drug delivery system. The nanogels were self-assembled from chitosan-based copolymers, chitosan-graft-poly(N-isopropylacrylamide) (CS-g-PNIPAm). The copolymers were synthesized via free radical copolymerization and characterized for their chemical structure by FT-IR and ¹H NMR. These copolymers could be efficiently loaded with oridonin (ORI) and the characteristics of ORI-loaded nanogels were evaluated. Drug release researches indicated that the ORI-loaded nanogels displayed pH-dependent release behaviors. Based on MTT assay and cellular morphological analysis, the anti-tumor activity of ORI-loaded nanogels was higher at pH 6.5 than at pH 7.4. In conclusion, the obtained nanogels appeared to be of great promise in tumor extracellular pH targeting for ORI.