In vitro studies of serum albumin interaction with poly(d,l-lactide) nanospheres loaded by hydrophobic cargo
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- 作者：Jadwiga Pietkiewicza ; jadwiga.pietkiewicz@umed.wroc.pl" class="auth_mail" title="E-mail the corresponding author ; Kazimiera A. Wilkb ; Urszula Bazylińskab
- 关键词：Polymeric nanocarriers ; Colloidal stability ; Nanosphere-serum albumin complexes
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2016
- 出版时间：5 January 2016
- 年：2016
- 卷：117
- 期：Complete
- 页码：426-435
- 全文大小：2067 K
文摘
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Poly(d,l-lactide) nanospheres loaded with IR-780, ZnPc or CUR were fabricated by the nanoprecipitation method.
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Dynamic light scattering and atomic force microscopy indicated desired nanocarriers shape and size for potential tumor delivery.
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UV–vis spectroscopy was applied to establish the binding of the nanocarrier with serum albumin as disopsonin.
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The binding of IR-780-loaded nanosphere occurred with lower efficiency than its analogs loaded with ZnPc or CUR.