Nausea was historically equated with seasickness. The prodromal signs and symptoms preceding vomiting can vary depending on the emetic trigger. Triggering stimuli used in laboratory studies of nausea may not elicit the same prodromal indicators as “real world” stimuli. A definition of nausea must consider that prodromal signs and symptoms can vary between individuals and triggering mechanisms. A variety of neural pathways can be activated by emetic stimuli, depending on the responses evoked in an individual.