Challenges and issues with streptozotocin-induced diabetes - A clinically relevant animal model to understand the diabetes pathogenesis and evaluate therapeutics
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- 作者：Sameer N. Goyala ; goyal.aiims@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Navya M. Reddya ; 1 ; mnrnavya33@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kalpesh R. Patilb ; 1 ; kalpeshpharma20@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Kartik T. Nakhatec ; Shreesh Ojhad ; shreeshojha@uaeu.ac.ae" class="auth_mail" title="E-mail the corresponding author ; Chandragouda R. Patila ; pchandragouda@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Yogeeta O. Agrawale ; goyalyogita@rediffmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：STZ ; Streptozotocin ; Diabetes ; Animal model ; Diabetic mortality ; STZ toxicity
- 刊名：Chemico-Biological Interactions
- 出版年：2016
- 出版时间：25 January 2016
- 年：2016
- 卷：244
- 期：Complete
- 页码：49-63
- 全文大小：2012 K
文摘
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STZ is used for screening of anti-diabetic and hypoglycemic drugs.
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STZ gives non-specific organ toxicities.
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STZ induced diabetes is clinically relevant and most widely used animal model.
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STZ induces a toxic effect on β cells through multiple mechanisms.
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Parallel use of d-Glucose, glutamine & tacrine reduces organ toxicities & mortality.