γδ T Cells Support Pancreatic Oncogenesis by Restraining αβ T Cell Activation
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- 作者：Donnele Daley1 ; 6 ; 7 ; Constantinos Pantelis Zambirinis1 ; 6 ; 7 ; Lena Seifert1 ; 6 ; 7 ; Neha Akkad1 ; Navyatha Mohan1 ; Gregor Werba1 ; Rocky Barilla1 ; Alejandro Torres-Hernandez1 ; Mautin Hundeyin1 ; Vishnu Raj Kumar Mani1 ; Antonina Avanzi1 ; Daniel Tippens1 ; Rajkishen Narayanan1 ; Jung-Eun Jang2 ; 3 ; Elliot Newman1 ; Venu Gopal Pillarisetty4 ; Michael Loran Dustin3 ; 5 ; Dafna Bar-Sagi2 ; Cristina Hajdu3 ; George Miller1 ; 6 ; 8 ; george.miller@nyumc.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：cancer ; Kras ; checkpoint ligands
- 刊名：Cell
- 出版年：2016
- 出版时间：8 September 2016
- 年：2016
- 卷：166
- 期：6
- 页码：1485-1499.e15
- 全文大小：13952 K
文摘
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γδT cells are highly prevalent in human pancreatic carcinoma
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Deletion or interruption of γδT cell recruitment is protective in pancreatic cancer
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Pancreatic cancer infiltrating γδT cells express high levels of checkpoint ligands
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γδT cells disable αβT cell activation via checkpoint receptor ligation