Characterization of a near-infrared fluorescent DCPO-tagged glucose analogue for cancer cell imaging

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• 作者：Yanfen Fang^a ; ¹ ; Wanli Zhang^a ; ¹ ; Mengli Zhu^a ; Shiguang Chen^b ; Xuan Liu^c ; Wei Lu^b ; ^{wlu@chem.ecnu.edu.cn} ; Xiongwen Zhang^a ; ^{xwzhang@sat.ecnu.edu.cn}
• 关键词：NIR ; Near-infrared ; 18F&ndash ; FDG ; 2-deoxy-2-(18F)fluoro-d-glucose ; PET ; positron emission tomography ; 6-NBDG ; 6-deoxy-N-(7-nitrobenz-2-oxa-l ; 3-diazol-4-yl)-aminoglucose ; 2-NBDG ; 2-[N-(7-nitrobenz-2-oxa-1.3-diazol-4-yl)-amino]-2-deoxyglucose ; 2-DG ; 2-deoxyglucose ; GLUTs ; glucose transporters ; DCPO ; (E)-2-(2-(4-Hydroxystyryl)-4H&ndash ; chromen-4-ylidene)-malononitrile ; RIPA ; Radio Immunoprecipitation Assay ; GAPDH ; glyceraldehyde-3-phosphate dehydrogenase
• 刊名：Journal of Photochemistry and Photobiology B: Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：166
• 期：Complete
• 页码：264-271
• 全文大小：1312 K
• 卷排序：166

文摘

GLUT-1 was overexpressed in hepatoma HepG2 cells and gastric cancer NCI-N87 cells. The cellular uptake of N2 was significant higher in cancer cells than normal cells. d-glucose or GLUT-1 inhibitor effectively inhibited the cellular uptake of N2. The cellular uptake of N2 was in a concentration- and time-dependent manner.