Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs
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- 作者：Xinlai Chenga ; x.cheng@uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Jee Young Kima ; J.Kim@uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Shahrouz Ghafoorya ; shahrouzghafoory@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Tijen Duvacia ; tijenduvaci@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Roya Rafieea ; roya.rafie@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jannick Theobalda ; jannick.theobald@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Hamed Alborziniaa ; Hamed.alborzinia@uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Pavlo Holenyaa ; Holenya@stud.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Johannes Fredebohmb ; J.Fredelbohm@dkfz.de" class="auth_mail" title="E-mail the corresponding author ; Karl-Heinz Merzc ; khmerz@rhrk.uni-kl.de" class="auth_mail" title="E-mail the corresponding author ; Arianeb Mehrabid ; arianeb.mehrabi@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Mohammadreza Hafezid ; mohammadreza.hafezi@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Arash Saffarid ; arash.saffari@med.uni-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Gerhard Eisenbrandc ; eisenbra@rhrk.uni-kl.de" class="auth_mail" title="E-mail the corresponding author ; Jö ; rg D. Hoheiselb ; J.Hoheisel@dkfz-heidelberg.de" class="auth_mail" title="E-mail the corresponding author ; Stefan Wö ; lfla ; wolfl@uni-hd.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Indirubin ; Meisoindigo ; Pancreatic cancer stem cell ; CSC drug ; LKB1 inactivation ; AMPK activation ; PDAC ; CD133
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：10
- 期：6
- 页码：806-824
- 全文大小：5229 K
文摘
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Meisoindigo is highly effective against gemcitabine-resistant PDAC.
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Meisoindigo preferentially targets CSC population.
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Meisoindigo interferes with cellular redox balance.
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Meisoindigo activates AMPK cascade, but inhibits LKB1.
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LKB1 knockdown mimics the effect of meisoindigo in CSCs.