Cytosolic Trypanosoma cruzi nucleoside diphosphate kinase generates large granules that depend on its quaternary structure
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- 作者：Claudio A. Pereira ; Chantal Reigada ; Melisa Sayé ; Fabio A. Digirolamo ; Mariana R. Miranda ; mirandamariana@gmail.com" class="auth_mail
- 关键词：Trypanosoma cruzi ; Nucleoside diphosphate kinase ; Granules ; Protein arrangement ; Oligomerization
- 刊名：Experimental Parasitology
- 出版年：July 2014
- 年：2014
- 卷：142
- 期：Complete
- 页码：43-50
- 全文大小：1661 K
文摘
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Nucleoside diphosphate kinase 1 (NDPK1) from Trypanosoma cruzi has a cytosolic localization.
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NDPK1 generates large membrane-free granules that depends on its hexameric structure.
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Granules are specific for the canonical isoform of NDPK.
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Granules are present in metacyclic trypomastigotes and stressed epimastigotes.