NECL1 coated PLGA as favorable conduits for repair of injured peripheral nerve
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- 作者：Fuben Xua ; b ; 1 ; Kun Zhangc ; d ; 1 ; Peizhen Lvc ; d ; Rongbin Luc ; d ; Li Zhenga ; e ; zhengli224@163.com" class="auth_mail" title="E-mail the corresponding author ; Jinmin Zhaoa ; d ; zhaojinmin@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Peripheral nerve injuries ; NECL1 ; PLGA ; Sciatic nerve ; Nerve regeneration
- 刊名：Materials Science & Engineering C
- 出版年：2017
- 出版时间：1 January 2017
- 年：2017
- 卷：70
- 期：part_P2
- 页码：1132-1140
- 全文大小：2358 K
文摘
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A fabricated PLGA tubes pre-coated with Nectin-like molecule 1 (NECL1) strategy for sciatic nerve regeneration is proposed.
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The NECL1 coated PLGA can promote Schwann cells adhesion and growth meanwhile maintain the phenotype cultured in vitro.
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PLGA/NECL1 tubes bridging the nerve defect can greatly enhance the functional recovery of nerve regeneration in vivo.
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The novel blend of PLGA/NECL1 conduits would be a candidate in biomedicine for tissue engineering scaffold.