Lipopolysaccharide- and β-1,3-glucan-binding protein from Fenneropenaeus merguiensis functions as a pattern recognition receptor with a broad specificity for diverse pathogens in the defense against microorganisms

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• 作者：Areerat Chaosomboon ; Benjaporn Phupet ; Onnicha Rattanaporn ; Phanthipha Runsaeng ; Prapaporn Utarabhand ; ^{prapaporn.u@psu.ac.th}
• 关键词：Lipopolysaccharide- and β-1 ; 3-glucan-binding protein (LGBP) ; Fenneropenaeus merguiensis ; Immune response ; Hepatopancreas ; Vibrio harveyi
• 刊名：Developmental & Comparative Immunology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：67
• 期：Complete
• 页码：434-444
• 全文大小：2841 K
• 卷排序：67

文摘

FmLGBP was cloned from Fenneropenaeus merguiensis hepatopancreas containing LGBP domains. LGBP mRNA expression was up-regulated upon challenge with pathogenic Vibrio harveyi. rLGBP could agglutinate and bind Gram-negative and Gram-positive bacteria and yeast. FmLGBP may serve as receptor molecules to recognize invading diverse microorganisms. FmLGBP may act as PRP in the innate immune response in this species of shrimp.