Amphiphilic azobenzene-neomycin conjugate self-assembles into nanostructures and transports plasmid DNA efficiently into the mammalian cells
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- 作者：Santosh Yadava ; c ; 1 ; Smriti Rekha Dekaa ; 1 ; Diksha Jhab ; Hemant Kumar Gautamb ; Ashwani Kumar Sharmaa ; ashwani@igib.res.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Self-assembly ; Azobenzene-neomycin ; Transfection efficiency ; Cytotoxicity ; Antimicrobial activity
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 December 2016
- 年：2016
- 卷：148
- 期：Complete
- 页码：481-486
- 全文大小：2474 K
文摘
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Azo-Neo self-assembles into nanostructures with hydrophobic core.
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Cationic Azo-Neo nanostructures binds pDNA efficiently.
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Azo-Neo/pDNA nanoassemblies enter the cells via endocytosis.
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These nanoassemblies exhibit efficient gene expression.
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Azo-AG nanostructures also show high antibacterial activity against MRSA.