Lichen Sclerosus and Squamous Cell Carcinoma

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• 作者：M. Gutié ; rrez-Pascual ; ^{mgutierrezpas@hotmail.com} ; F.J. Vicente-Martí ; n ; J.L. Ló ; pez-Estebaranz
• 关键词：Lichen sclerosus ; Squamous cell carcinoma ; Verrucous carcinoma ; Human papilloma virus ; Vulvar intraepithelial neoplasia ; Penile intraepithelial neoplasia
• 刊名：Actas Dermo-Sifiliogr¡§¡éficas (English Edition)
• 出版年：2012
• 出版时间：January-February, 2012
• 年：2012
• 卷：103
• 期：1
• 页码：21-28
• 全文大小：1310 K

文摘

Lichen sclerosus is a chronic inflammatory disease that can progress to malignancy. The literature indicates an association with anogenital squamous cell carcinoma and verrucous carcinoma. Two pathogenic pathways, differentiated vulvar and penile intraepithelial neoplasias, which have recently been described in relation to squamous cell carcinoma, are both highly associated with genital lichen sclerosus independently of human papilloma virus (HPV) infection. Furthermore, tumor-promoting molecular changes unrelated to HPV infection have been demonstrated and may explain the malignant potential of lichen sclerosus. The possible relationship between HPV and genital lichen sclerosus currently remains open to discussion, and the prognostic importance of the overlapping of these 2 diseases is still unclear. This review considers the relationship between lichen sclerosus and squamous cell and verrucous carcinomas, the possible oncogenic mechanisms involved, and their possible association with HPV infection.