Mechanisms contributing to myocardial potassium channel diversity, regulation and remodeling

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• 作者：Kai-Chien Yang ; MD ; PhD^a ; ^b ; Jeanne M. Nerbonne ; PhD^c ; ^d ; ^e ; ^{jnerbonne@wustl.edu" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Myocardial excitability ; Arrhythmias ; MicroRNAs ; Transcription factors ; Long non-coding RNAs ; Cardiac hypertrophy ; Heart failure ; Diabetes
• 刊名：Trends in Cardiovascular Medicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：26
• 期：3
• 页码：209-218
• 全文大小：1055 K

文摘

In the mammalian heart, multiple types of K⁺ channels contribute to the control of cardiac electrical and mechanical functioning through the regulation of resting membrane potentials, action potential waveforms and refractoriness. There are similarly vast arrays of K⁺ channel pore-forming and accessory subunits that contribute to the generation of functional myocardial K⁺ channel diversity. Maladaptive remodeling of K⁺ channels associated with cardiac and systemic diseases results in impaired repolarization and increased propensity for arrhythmias. Here, we review the diverse transcriptional, post-transcriptional, post-translational, and epigenetic mechanisms contributing to regulating the expression, distribution, and remodeling of cardiac K⁺ channels under physiological and pathological conditions.