NMR study of hydroxy and amide protons in hyaluronan polymers

详细信息    查看全文

• 作者：Gustav Nestor ^{gustav.nestor@slu.se} ; Corine Sandströ ; m ; ^{corine.sandstrom@slu.se}
• 关键词：HA ; hyaluronan/hyaluronic acid ; MD ; molecular dynamics ; HR- ; MAS high-resolution magic angle spinning ; NOE ; nuclear Overhauser effect ; TOCSY ; total correlation spectroscopy ; NOESY ; nuclear Overhauser effect spectroscopy ; ROESY ; rotating-frame nuclear Overhauser effect spectroscopy ; BPP-LED ; bipolar-pulse pair longitudinal eddy-current delay
• 刊名：Carbohydrate Polymers
• 出版年：2017
• 出版时间：10 February 2017
• 年：2017
• 卷：157
• 期：Complete
• 页码：920-928
• 全文大小：1291 K
• 卷排序：157

文摘

Hydroxy and amide protons of hyaluronan polymers were studied by NMR spectroscopy. Transient hydrogen bonds were confirmed over the glycosidic linkages of hyaluronan. No direct inter-chain interactions involving hydroxy protons were found. The interior of a hyaluronan oligosaccharide represents well the polymer structure. NOEs suggested a different orientation of the amide proton in the polymer.