Downregulation of bone morphogenetic protein receptor 2 promotes the development of neuroblastoma

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• 作者：Ximao Cui^a ; Yili Yang^b ; Deshui Jia^c ; Ying Jing^c ; Shouhua Zhang^d ; Shan Zheng^a ; Long Cui^e ; Rui Dong^a ; ^{dongrui_1982@126.com} ; Kuiran Dong^a ; ^{kuirand@hotmail.com}
• 关键词：Neuroblastoma ; BMPR2 ; Pediatrics ; Proliferation ; Cancer
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：609-616
• 全文大小：2195 K
• 卷排序：483

文摘

BMPR2 expression was downregulated in primary NB and was more signifcant in high grade NB. BMPR2 expression was accompanied by the decrease of NB markers ferritin and enolase. Enforced expression of BMPR2 decreased proliferation and colony formation ability of cultured NB cells. Knockdown of BMPR2 led to increased cell growth, clonality and tumorigenicity in mice. Patients with NB expressing higher level of BMPR2 had significant better overall survival than those with low level.