Molecular neurobiology of mTOR

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• 作者：Katarzyna Switon^a ; Katarzyna Kotulska^b ; Aleksandra Janusz-Kaminska^a ; Justyna Zmorzynska^a ; Jacek Jaworski^a ; ^{jaworski@iimcb.gov.pl}
• 关键词：4E-BPs ; 4E-binding proteins ; Atg13 ; autophagy-related protein 13 ; BDNF ; brain-derived neurotrophic factor ; CGG ; trinucleotide ; EGF ; epidermal growth factor ; FXS ; Fragile X syndrome ; Hif1α ; hypoxia-inducible factor 1-α ; LTD ; long-term depression ; LTP ; long-term potentiation ; MAMs ; mitochondrion-associated membranes ; mTOR ; mammalian/mechanistic target of rapamycin ; NSC ; neural stem cell ; p70S6K1 ; p70 ribosomal S6 protein kinase 1 ; PKC ; protein kinase C ; Rheb ; Ras homolog enriched in brain protein
• 刊名：Neuroscience
• 出版年：2017
• 出版时间：26 January 2017
• 年：2017
• 卷：341
• 期：Complete
• 页码：112-153
• 全文大小：2064 K
• 卷排序：341

文摘

mTOR kinase links extracellular signals with intracellular resources. mTOR controls transcription, translation, protein degradation and cytoskeleton. mTOR regulates neuronal development and plasticity. mTOR activity is disturbed in neurodevelopmental and neurodegenerative diseases. mTOR-related neuropathology stems from combined failure of many cellular processes.