Sensory deprivation increases phagocytosis of adult-born neurons by activated microglia in the olfactory bulb

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• 作者：Marie Denizet ^{marie.denizet@pasteur.fr} ; Laurent Cotter ^{laurent.cotter@pasteur.fr} ; Pierre-Marie Lledo ; ^{pierre-marie.lledo@pasteur.fr} ; Franç ; oise Lazarini ; ^{lazarini@pasteur.fr}
• 关键词：Adult neurogenesis ; Hyposmia ; Neuroinflammation ; LPS ; Spines
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：60
• 期：Complete
• 页码：38-43
• 全文大小：1935 K
• 卷排序：60

文摘

We assessed the interactions between microglia and interneurons in the olfactory bulb (OB) following acute inflammation induced by either sensory deafferentation or intranasal lipopolysaccharide (LPS) administration. Microglia engulfed more adult-born neurons in the deafferented OB compared to sham counterparts. These data suggest a key role of microglia in activity-associated shaping of neuronal connexions.