TRIM46 Controls Neuronal Polarity and Axon Specification by Driving the Formation of Parallel Microtubule Arrays
详细信息 查看全文
- 作者：Sam F.B. van Beuningen1 ; Lena Will1 ; Martin Harterink1 ; Anaë ; l Chazeau1 ; Eljo Y. van Battum2 ; Cá ; tia P. Frias1 ; Mariella A.M. Franker1 ; Eugene A. Katrukha1 ; Riccardo Stucchi1 ; 3 ; Karin Vocking1 ; Ana T. Antunes1 ; Lotte Slenders1 ; Sofia Doulkeridou1 ; Peter Sillevis Smitt4 ; A.F. Maarten Altelaar3 ; Jan A. Post1 ; Anna Akhmanova1 ; R. Jeroen Pasterkamp2 ; Lukas C. Kapitein1 ; Esther de Graaff1 ; e.degraaff@uu.nl" class="auth_mail" title="E-mail the corresponding author ; Casper C. Hoogenraad1 ; c.hoogenraad@uu.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：neuronal polarity ; axon formation ; axon initial segment ; cytoskeleton ; microtubule ; transport ; parallel bundles ; fascicles ; cross-bridges ; TRIM
- 刊名：Neuron
- 出版年：2015
- 出版时间：16 December 2015
- 年：2015
- 卷：88
- 期：6
- 页码：1208-1226
- 全文大小：9983 K
文摘
- •
TRIM46 specifically localizes to the proximal axon
- •
TRIM46 forms closely spaced, parallel microtubule fascicles
- •
TRIM46 is needed for uniform axonal microtubule orientation
- •
TRIM46 is required for axon specification and neuronal polarity in vitro and in vivo