The diversity of circulating neutrophils in cancer

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• 作者：Inbal Mishalian^a ; Zvi Granot^b ; Zvi G. Fridlender^a ; ^{fridlender@hadassah.org.il" class="auth_mail" title="E-mail the corresponding author} ; ^{zvi_f@yahoo.com" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Neutrophils ; Cancer ; Tumor immunology
• 刊名：Immunobiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：222
• 期：1
• 页码：82-88
• 全文大小：1126 K

文摘

Neutrophils, the most abundant leukocyte in human circulation are being more and more recognized as part of the immune reaction to cancer. In the last years, the understanding that neutrophils possess a dual role in cancer development has emerged. During tumor progression the number of neutrophils increase, and their phenotype change. In advanced cancer, we can find several sub-populations of circulating neutrophils possessing different characteristics of maturity, tumor cytotoxicity and immune suppression. One important sub-population of circulating neutrophils is the granulocytic myeloid derived suppressor cells (G-MDSC). Differencing G-MDSC from other sub-populations of neutrophils in the circulation is a complex and controversial task, as there are no clear definitions of the differences between these granulocytic sub-populations. Herein we review the differences described thus far between G-MDSC and other circulating neutrophils. We then compare the morphology, surface markers, function and prognostic importance of the different tumor-related circulating neutrophils, as described by us and others, and discuss the possible relations between the different sub-populations, their source and fate. Lastly, we suggest a nomenclature to try and encompass the full range of circulating neutrophils in cancer.