Construction of recombinant baculovirus vaccines for Newcastle disease virus and an assessment of their immunogenicity
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- 作者：Jingping Ge ; Ying Liu ; Liying Jin ; Dongni Gao ; Chengle Bai ; Wenxiang Ping ; wenxiangp@aliyun.com.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Newcastle disease virus ; F gene ; HN gene ; Baculovirus expression vector system ; Immunogenicity
- 刊名：Journal of Biotechnology
- 出版年：2016
- 出版时间：10 August 2016
- 年：2016
- 卷：231
- 期：Complete
- 页码：201-211
- 全文大小：2194 K
文摘
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Newcastle Disease Virus (NDV) is an infectious poultry disease with high mortality.
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Baculovirus vaccines were engineered expressing the NDV F and HN proteins.
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The F-series was more immunogenic and offered better protection than the HN-series.
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WPRE and VSV-GED elements increased vaccine immunogenicity and antigen expression.
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Internal terminal repeats (ITRs) increased the duration of the cytokine response.