Neutrophil gelatinase-associated lipocalin and microglial activity are associated with distinct postoperative behavioral changes in rats

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• 作者：Leonie Gouweleeuw^a ; ¹ ; ^{l.gouweleeuw@rug.nl} ; Iris B. Hovens^a ; ^b ; ¹ ; ^{i.b.hovens@rug.nl} ; Barbara L. van Leeuwen^b ; ^{b.l.van.leeuwen@umcg.nl} ; Regien G. Schoemaker^a ; ^{r.g.schoemaker@umcg.nl}
• 关键词：Neutrophil gelatinase-associated lipocalin ; Microglia ; Neuroinflammation ; Postoperative cognitive dysfunction ; Behavior
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：319
• 期：Complete
• 页码：104-109
• 全文大小：869 K
• 卷排序：319

文摘

We explored the link between postoperative NGAL and behavior in a POCD rat model. Plasma and hippocampal NGAL were increased postoperatively. Plasma NGAL is associated with postoperative spatial learning impairment. Microglial activity is associated with reduced postoperative exploratory behavior. NGAL may be a sensitive marker connecting the peripheral inflammatory state to POCD.